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It was the discovery of melatonin synthesis in endocrine organs, namely the pineal gland, neural frameworks, and immunocompetent cells such as T lymphocytes, NK cells, as well as mast cells that activated the new methods to the unifield signal guideline of homeostasis, which, at the turn of the 21st century, bring about the production of a brand-new important biomedical discipline - neuroimmunoendocrinology.
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